Functional connectivity of DMN is underestimated due to signal loss in parahippocampal regions and its remedy
Yu-Sheng Tseng 1 , Teng-Yi Huang 1 , and Yi-Jui Liu 2
National Taiwan University of Science and
Technology, Taipei, Taiwan,
Chia University, Taichung, Taiwan
The study of Grecius et al. indicated that default mode
network (DMN) is closely involved with memory processing
and resting-state activity in the posterior cingulate
cortex (PCC) and hippocampus decreases in the AD group.
However, in their study, the hippocampal coactivation in
DMN was almost absent when the GE-EPI images were
acquired using a 3.0 T MRI scanner. Grecius et al.
suggested that the signal loss of hippocampus is most
likely due to susceptibility artifacts at 3.0 T1. We
assume that optimization of slice orientation reduces
signal loss of the human hippocampus area and improves
measurements of functional connectivity of DMN. In this
study, we investigate the signal intensities of GE-EPI
images and functional connectivity of DMN using three
conventional slice orientations.
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