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Abstract #4744

Functional connectivity of DMN is underestimated due to signal loss in parahippocampal regions and its remedy

Yu-Sheng Tseng 1 , Teng-Yi Huang 1 , and Yi-Jui Liu 2

1 National Taiwan University of Science and Technology, Taipei, Taiwan, 2 Feng Chia University, Taichung, Taiwan

The study of Grecius et al. indicated that default mode network (DMN) is closely involved with memory processing and resting-state activity in the posterior cingulate cortex (PCC) and hippocampus decreases in the AD group. However, in their study, the hippocampal coactivation in DMN was almost absent when the GE-EPI images were acquired using a 3.0 T MRI scanner. Grecius et al. suggested that the signal loss of hippocampus is most likely due to susceptibility artifacts at 3.0 T1. We assume that optimization of slice orientation reduces signal loss of the human hippocampus area and improves measurements of functional connectivity of DMN. In this study, we investigate the signal intensities of GE-EPI images and functional connectivity of DMN using three conventional slice orientations.

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