Brain imaging results identify structural and vascular abnormalities in type 2 diabetic adults compared to hypertensive controls
Ekaterina Tchistiakova 1,2 , Carol E. Greenwood 3,4 , Nicole D. Anderson 3,5 , and Bradley J. MacIntosh 1,2
Medical Biophysics, University of Toronto,
Toronto, ON, Canada,
and Stroke Foundation Canadian Partnership for Stroke
Recovery, Sunnybrook Research Institute, Toronto, ON,
Research Institute, Baycrest, Toronto, ON, Canada,
of Nutritional Sciences, University of Toronto, Toronto,
of Medicine (Psychiatry), University of Toronto,
Toronto, ON, Canada
Recent studies suggest that the negative effects of type
2 diabetes (T2DM) on the brain can result in increased
risk of cognitive decline and dementia. It is still
unclear, however, if T2DM effects exceed those seen in
co-occurring comorbidities, in particular hypertension (HTN).
In this study imaging metrics were used to compare brain
structure and vascular integrity between individuals
with T2DM and HTN and hypertensive controls. Our results
demonstrate regional decreases in vascular reactivity
and tissue volume (i.e. cortical thinning) in the right
visual processing regions in individuals with T2DM and
HTN compared to HTN alone.
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