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Abstract #4774

Differential Diagnosis of MELAS and Ischemic Stroke using 3D Pseudocontinuous Arterial Spin Labeling

Xin Lou 1 , Lin Ma 1 , Diandian Huang 1 , and Kaining Shi 2

1 Department of Radiology, Chinese PLA General Hospital, Beijing, Beijing, China, 2 MR Research (China), General Electric Company GE ( China ) Co., Ltd.-Healthcare, Beijing, Beijing, China

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and a stroke-like episode) is a mitochondrial disorder that the neurological deficits and imaging characteristics resemble features of ischemic stroke. Our study suggest that three dimensional pseudo-continuous arterial spin labelling, an alternative noninvasive perfusion technique based on fast spin echo sequence, is useful in differentiating MELAS from ischemic stroke when clinical symptoms and conventional MRI manifestations overlap in these two conditions.

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