Meeting Banner
Abstract #4783

Fractional Anisotropy Changes of White matter Infarction and Hypoperfusion in Patients with Hyperacute Stroke: A Voxel-based Analysis Using DTI and DSC Perfusion

Kambiz Nael 1 , Scott R Lafleur 1 , Adam Bernstein 1 , Bruce M Coull 2 , Chelsea S Kidwell 2 , Elizabeth A Krupinski 1 , and Theodore P Trouard 1

1 Medical Imaging, University of Arizona, Tucson, AZ, United States, 2 Neurology, University of Arizona, Tucson, AZ, United States

The DTI-fractional anisotropy (FA) changes in acute infarction are variable between the infarction core and ischemic regions depending on the severity of ischemia and time of onset. In this study, using a combination of DTI and DSC perfusion, we conducted a voxel-based analysis of FA changes in the white matter infarction and hypoperfusion using defined thresholds. We found significant reduction of FA values in the infarction white matter indicative of loss of cellular integrity. In addition, the FA values were significantly higher in the hypoperfused white matter with Tmax 6 suggestive of microstructural changes related to ischemia without cell membrane disruption.

This abstract and the presentation materials are available to members only; a login is required.

Join Here