Fractional Anisotropy Changes of White matter Infarction and Hypoperfusion in Patients with Hyperacute Stroke: A Voxel-based Analysis Using DTI and DSC Perfusion
Kambiz Nael 1 , Scott R Lafleur 1 , Adam Bernstein 1 , Bruce M Coull 2 , Chelsea S Kidwell 2 , Elizabeth A Krupinski 1 , and Theodore P Trouard 1
Medical Imaging, University of Arizona,
Tucson, AZ, United States,
University of Arizona, Tucson, AZ, United States
The DTI-fractional anisotropy (FA) changes in acute
infarction are variable between the infarction core and
ischemic regions depending on the severity of ischemia
and time of onset. In this study, using a combination of
DTI and DSC perfusion, we conducted a voxel-based
analysis of FA changes in the white matter infarction
and hypoperfusion using defined thresholds. We found
significant reduction of FA values in the infarction
white matter indicative of loss of cellular integrity.
In addition, the FA values were significantly higher in
the hypoperfused white matter with Tmax 6 suggestive
of microstructural changes related to ischemia without
cell membrane disruption.
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