Abstract #4875
Gd-enhanced MRI after therapeutic ferumoxytol for iron deficiency anemia - An in-vitro study for optimal contrast timing and dose determination.
Sandeep Arora 1 , Judy Yee 1 , David Saloner 1 , Rizwan Aslam 1 , and Thomas Hope 1
1
Radiology and Biomedical Imaging, University
of California, San Francisco, San Francisco, California,
United States
Therapeutic ferumoxytol injections can confound
subsequently performed magnetic resonance imaging using
gadolinium based contrast agents due to its
superparamagnetic effects. In this in vitro study, we
image various concentrations of ferumoxytol and
gadolinium to determine concentration of ferumoxytol
which will not affect arterial enhancement in subsequent
contrast enhanced scans. Our images demonstrate that
significant enhancement can be seen after single dose
gadolinium enhanced scans two half-lives with initial
ferumoxytol concentration being 300 microgram/ml. Even
after one half-life, significant enhancement can be seen
with double or triple dosing of gadolinium based
contrast agents.
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