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Abstract #4916

An untargeted metabolomics approach to ultra high field MRS in spinocerebellar ataxia

Uzay Emrah Emir 1,2 , Margarida Juli-Sap 3 , Peter Jezzard 1 , Diane Hutter 2 , Khalaf O Bushara 2 , and Gulin Oz 2

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 University of Minnesota, Minneapolis, Minnesota, United States, 3 Centro de Investigacin Biomdica en Red en Bioingeniera, Biomateriales y Nanomedicina (CIBER-BBN), Universitat Autnoma de Barcelona, Cerdanyola del Valls, Spain

A metabolomics approach to analyzing in vivo MRS data might benefit substantially from ultra high field (UHF) due to the improved sensitivity and resolution. In this study, we explored the potential of a metabolomics approach to MRS by comparing patients with spinocerebellar ataxia type 1 (SCA1) to healthy controls both at 3T and 7T. Due to high spectral quality at both fields, distinct clustering with a complete separation between SCA1 and controls was achieved. The improved sensitivity and resolution at 7T enabled identification of three distinct spectral features whereas only 2 distinct features were identified at 3T.

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