Ultra-high Resolution In-vivo 7.0T Structural Imaging of the Human Endfolial Pathway
Mansi Parekh 1 , Ryan Purcell 2 , Sherveen Parivash 1 , Brian Rutt 1 , and Michael Zeineh 1
Radiology, Stanford University, Stanford,
CALIFORNIA, United States,
University College London, London, United Kingdom
The hippocampal hilus may have unique neuroanatomy in
humans compared to monkeys and rodents, with CA3h
greatly enlarged and a unique white-matter pathway
called the endfolial pathway present. In this stud,y we
used newly developed 7.0T whole brain imaging achieving
0.4mm isotropic images to study in vivo the anatomy of
the hippocampal hilus. We validate these in vivo finding
with 0.1mm isotropic excised specimen images as well as
histologically using a myelin stain. The endfolial
pathway is a central pathway in the hippocampus,
possibly unique to humans, and poorly described.
However, our methodology will allow for its study and
understanding its function.
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