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Abstract #4934

Optimization of Magnetization Prepared Rapid Gradient Echo (MP-RAGE) at 7T

Manojkumar Saranathan 1 , Thomas Tourdias 1 , May Han 2 , and Brian K Rutt 1

1 Department of Radiology, Stanford University, Stanford, CA, United States, 2 Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States

The purpose of this work was to optimize MP-RAGE imaging at 7T. Two regimes- a conventional cerebral spinal fluid nulled (CSFn) and a white-matter nulled (WMn) MP-RAGE for imaging cortical lesions and thalamus-were optimized for scan time, SNR and contrast efficiency. The effect of α and TR on image blurring was modeled and validated. A novel 2D-centric radial fanbeam (RFB) k-space segmentation scheme was used for reducing scan times. Finally, healthy human subjects and patients with multiple sclerosis (MS) were scanned at 7T to demonstrate novel lesion detectability.

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