Abstract #0011
Frequency difference mapping for measurement of white matter microstructure
Benjamin Tendler 1 , Samuel Wharton 1 , and Richard Bowtell 1
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom
Frequency difference mapping (FDM) is a novel technique
that takes advantage of the non-linear temporal
evolution of the phase in gradient echo sequences to
obtain images that carry information about white matter
(WM) microstructure. In contrast to other phase-based
approaches for probing WM properties such as QSM and
STI, FDM can yield local contrast that is sensitive to
microstructure without requiring sophisticated filtering
of phase images. Here a straightforward implementation
of FDM is presented. The application of this approach to
the measurement of the variation of microstructure
across the corpus callosum in a study of 10 subjects is
also described.
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