Can Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer (NOE-CEST) Offer a New Insight in Acute Stroke Diagnosis?
Yee Kai Tee 1 , George WJ Harston 2 , Nicholas Blockley 3 , Robert Frost 3 , Thomas W Okell 3 , Sivarajan Thandeswaran 2 , Fintan Sheerin 4 , Peter Jezzard 3 , James Kennedy 2 , Stephen Payne 5 , and Michael Chappell 5
Department of Mechatronics and BioMedical
Engineering, Universiti Tunku Abdul Rahman, KL, KL,
Stroke Programme, Radcliffe Department of Medicine,
Oxford University, Oxfordshire, United Kingdom,
Centre of Functional MRI of the Brain, Nuffield
Department of Clinical Neurosciences, Oxford University,
Oxfordshire, United Kingdom,
of Neuroradiology, Oxford University Hospitals NHS
Trust, Oxfordshire, United Kingdom,
of Engineering Science, Institute of Biomedical
Engineering, Oxford University, Oxfordshire, United
Chemical exchange saturation transfer (CEST) data in
acute stroke patients (within 6 hours of onset) were
acquired to compare nuclear Overhauser enhancement
mediated CEST (NOE-CEST) with apparent diffusion
coefficient (ADC) and pH-weighted imaging using amide
proton transfer (APT). This work is the first
demonstration of NOE-CEST in acute human stroke.
NOE-CEST provides a unique contrast compared to ADC and
pH-weighted imaging in tissue that progresses to
infarction, suggesting that NOE-CEST may offer a new
insight in acute stroke management.
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