Inter-Scanner Reliability of Graph-Theoretic Brain Network Metrics
Thomas Welton 1 , Dorothee P Auer 1 , and Robert A Dineen 1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
We tested the between-scanner reliability of
graph-theoretic brain network properties derived from
resting-state fMRI data. This is a crucial prerequisite
to the wider application of graph metrics in clinical
neuroscience and, in particular, to future adoption in
multicentre treatment trials. Using data from five
healthy subjects scanned in 10 different scanners, we
show that overall reliability was poor. Scanner field
strength was not associated with reliability, but
averaging over repeat scans did improve reliability.
Graph metrics derived from human brain fMRI data are not
yet reliable enough between scanners for use as
surrogate outcomes in multicentre clinical trials.
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