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Abstract #0065

MRI Tracked Tumor Physiology in the Hours after 20 Gy Single-Fraction Radiation

Rasha M. Elmghirbi 1,2 , Stephen L. Brown 3 , Tavarekere N. Nagaraja 4 , Madhava P. Aryal 2,5 , Kelly Ann Keenan 4 , Swayamprav Panda 2 , Hassan Bagher-Ebadian 2 , and James R. Ewing 1,2

1 Physics, Oakland University, Rochester, MI, United States, 2 Neurology, Henry Ford Health System, Detroit, MI, United States, 3 Radiation Oncology, Henry Ford Health System, Detroit, MI, United States, 4 Anesthesiology, Henry Ford Health System, Detroit, MI, United States, 5 Radiation Oncology, University of Michigan, Ann Arbor, MI, United States

The acute response in a U251 rat model of embedded cerebral tumor high-dose radiotherapy (HD-RT) is studied by measuring blood flow and vascular parameters in the tumor, and tissue compression in the periphery of the tumor. At 2 and 4 hours post HD-RT a profound decrease in tumor blood flow accompanies a significant decrease in extracellular space in both the tumor and its periphery. Decoupling of tissue compression and blood flow occurs about 8 hours after HD-RT.

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