Dose and Volume Effects of Radiation on White Matter in Children Treated for Medulloblastoma
Iska Moxon-Emre 1,2 , Eric Bouffet 1 , Michael D Taylor 1,2 , Normand Laperriere 2,3 , Michael Sharpe 2,3 , Suzanne Laughlin 1 , Nadia Scantlebury 1 , Nicole Law 1,2 , David Malkin 1,2 , Jovanka Skocic 1 , Logan Richard 1,2 , and Donald Mabbott 1,2
Hospital for Sick Children, Toronto,
of Toronto, Toronto, Ontario, Canada,
Health Network, Toronto, Ontario, Canada
This study examined white matter (WM) in children
treated for medulloblastoma with different clinically
relevant radiation dose and boost volumes, using
diffusion tensor imaging (DTI). We found that relative
to controls, patients treated with higher doses and/or
larger boost volumes show more compromised WM than
patients treated with the least intensive therapy (i.e.
reduced dose CSR and a boost limited to the tumor bed).
This was particularly evident in the temporal lobes, a
brain region encompassed by a lateral beam boost to the
posterior fossa (PF). Our findings suggest the PF boost
should be avoided whenever possible.
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