Abstract #0070
Comparison of diffusion and perfusion parameters in distinguishing radiation effect and necrosis from GBM
Melissa A Prah 1 , Mona M Al-Gizawiy 1 , Wade M Mueller 2 , Raymond G Hoffmann 3 , Mahua Dasgupta 3 , and Kathleen M Schmainda 1,4
1
Radiology, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Pediatrics, Medical College of
Wisconsin, Milwaukee, WI, United States,
4
Biophysics,
Medical College of Wisconsin, Milwaukee, WI, United
States
In brain tumor patients, pseudoprogression, which
results from an inflammatory response associated with
necrotic and radiation induced changes, has been shown
to mimic early tumor progression on standard imaging.
The goal of this study was to compare the ability of
diffusion and perfusion parameters in differentiating
radiation effect/necrosis (RE/Necrosis) from
glioblastoma (GBM). Using tissue samples
spatially-correlated to pre-surgical imaging, this work
demonstrates that relative cerebral blood volume (rCBV)
better distinguishes RE/Necrosis from GBM than relative
cerebral blood flow or the apparent diffusion
coefficient. Spatially visualizing differentiated
regions of RE/Necrosis and GBM with rCBV may ultimately
impact treatment management decisions.
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