Off-resonance positive contrast flow imaging using extraneous paramagnetic biomarker-induced spin labeling
Jessica A.M. Bastiaansen 1,2 , Helene Feliciano 1,2 , Andrew Coristine 1,2 , and Matthias Stuber 1,2
Department of Radiology, University Hospital
(CHUV) and University of Lausanne (UNIL), Lausanne,
for Biomedical Imaging (CIBM), Lausanne, Switzerland
By exploiting the frequency dispersion of protons
residing in the dipolar field of FeO constrast agents
that are injected intravenously, positive contrast MRI
is enabled. Here, off-resonance imaging was exploited to
explore positive contrast generation by using extraneous
paramagnetic biomarkers, specifically targeting the
labeling of moving protons. Spin labeling was thus
achieved in a flow phantom using off-resonant imaging.
Different delay times of the saturation pulse lead to a
more extensive range of labeled spins, and time resolved
positive contrast imaging of downstream areas. It allows
for flow visualization in the vicinity of paramagnetic
objects without the need for contrast injection.
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