Abstract #0112
Validation of diffusion tensor imaging of articular cartialge in an animal model of posttraumatic osteoarthritis
Jose G Raya 1 , Ignacio Rossi 1 , Oran Kennedy 1 , Natalie Danna 1 , Bryan Beutel 1 , You Jin Lee 1 , and Thorsten Kirsch 1
1
NYU Langone Medical Center, New York, NY,
United States
We validate DTI of articular cartilage in an animal
model of posttraumatic osteoarthritis (PTOA). Eight New
Zeeland white rabbits underwent anterior cruciate
ligament transection (ACLT) on one of the hindlimbs and
sham surgery in the contralateral limb. Rabbits were
scarified at 4 (n=4) and 8 weeks (n=4) after surgery.
Both joints underwent MRI (PD-weighted and DTI),
micro-CT and histology with safranin O. We observe a
trend of increased MD in the ACLT joints compared to the
sham that was significant at 8 weeks. Changes in MD
correlated with areas of PG loss in histology, that only
show changes on PG
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