Abstract #0117
Determination of correlation time in articular cartilage by T1rho relaxation dispersion
Matti Hanni 1,2 , Mikko J. Nissi 3,4 , Jari Rautiainen 3,4 , Simo Saarakkala 2,5 , Jutta Ellermann 6 , and Miika T. Nieminen 2,7
1
Department of Radiology, University of Oulu,
Oulu, Finland,
2
Medical
Research Center Oulu, Oulu University Hospital and
University of Oulu, Oulu, Finland,
3
Department
of Radiology, and Medical Research Center Oulu,
University of Oulu and Oulu University Hospital, Oulu,
Finland,
4
Department
of Applied Physics, University of Eastern Finland,
Kuopio, Finland,
5
Department
of Diagnostic Radiology, Oulu University Hospital,
Department of Medical Technology, University of Oulu,
Oulu, Finland,
6
Center
for Magnetic Resonance Research, Department of
Radiology, University of Minnesota, Minneapolis,
Minnesota, United States,
7
Department
of Diagnostic Radiology, University of Oulu and Oulu
University Hospital, Oulu, Finland
Reorientational correlation time is a fundamental
biophysical property that describes the dynamics of
nuclei in any type of tissue. In this abstract,
correlation time is investigated as a potential new MRI
contrast. It is obtained from MRI T1rho relaxation
dispersion measurements of bovine and human articular
cartilage in vitro. The fitted correlation times appear
to be macromolecule-specific, as well as indicative of
early structural changes associated with osteoarthritis.
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