Abstract #0146
MR Tagging-based liver elasticity study with the use of full strain tensor analysis for better understanding of mechanical alterations in NAFLD
Anna Orzylowska 1 , Krzysztof Jasinski 1 , Pawel T. Jochym 2 , Edyta Maslak 3 , and Tomasz Skorka 1
1
Department of Magnetic Resonance Imaging,
Institute of Nuclear Physics Polish Academy of Sciences,
Krakow, Poland,
2
Department
of Materials Research by Computers, Institute of Nuclear
Physics Polish Academy of Sciences, Krakow, Poland,
3
Department
of Endothelium Experimental Pharmacology, Jagiellonian
Center for Experimental Therapeutics (JCET), Krakow,
Poland
The purpose was to develop MR tagging (MRt) based
cardiac-induced liver deformation analysis for the
assessment of liver elasticity in mouse model of
non-alcoholic fatty liver disease (NAFLD). The
deformation was computed from MRt images as the maps of
principal strains, fractional volume changes, and
absolute strain magnitude, and quantified using
two-dimensional central and invariant image moments. In
NAFLD, the deformed area within all maps was more
irregular in comparison to Controls. The central and
invariant moments revealed decreased strain area and
level. The proposed method provided a routine suitable
for in-vivo measurements of the liver elasticity
impairement in NAFLD.
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