Abstract #0153
Characterization of the Wallerian degeneration process in the rat spinal cord with DIAMOND and NODDI: comparison with histological obervations.
Damien Jacobs 1 , Benoit Scherrer 2 , Aleksandar Jankovski 3 , Anne des Rieux 4 , Maxime Taquet 1 , Bernard Gallez 4 , Simon K. Warfield 2 , and Benoit Macq 1
1
ICTEAM, Universite catholique de Louvain,
Louvain-La-Neuve, Belgium,
2
Computational
Radiology Laboratory, Boston Childrens Hospital,
Massachusetts, United States,
3
Hopital
universitaire Mont-Godinne, Universite catholique de
Louvain, Godinne, Belgium,
4
LDRI,
Universite catholique de Louvain, Brussels, Belgium
The purpose is to investigate, for diffusion compartment
models (NODDI and DIAMOND), the variations of diffusion
parameters after Wallerian degeneration in the rat
spinal cord. The values of diffusion parameters for
NODDI and DIAMOND provide different informations and
both models are investigated in the case of the
Wallerian degeneration process. The alterations of each
diffusion parameters are highlighted after an unilateral
rhizotomy and the results are compared with the
histological observations (myelin, neurofilaments,
microglia, astrocytes).
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