A processing pipeline and anisotropic diffusion phantom to calibrate DTI experiments
Alexandru V. Avram 1 , Michal E. Komlosh 1,2 , Alan S. Barnett 1,2 , Elizabeth Hutchinson 1,2 , Dan Benjamini 1,3 , and Peter J. Basser 1
Section on Tissue Biophysics and
Biomimetics, NICHD, National Institutes of Health,
Bethesda, MD, United States,
Henry Jackson Foundation, Bethesda, MD, United States,
of Biomedical Engineering, Tel-Aviv University,
Experimental design and environmental factors can bias
the quantitation of anisotropic diffusion using
DTI-derived metrics, such as FA, compromising the value
of longitudinal data and multicenter clinical studies.
We propose the use of a novel anisotropic diffusion
phantom in conjunction with a general method for
modeling the diffusion signal produced by that phantom
using the details of the DWI pulse sequence and the
multiple correlation function (MCF) framework. The
well-defined and known microstructure of the phantom
generates a wide range of DTI parameters that can be
used to calibrate various DTI pulse sequences and
optimize clinical DTI protocols.
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