Changes in White-matter Integrity and Evoked fMRI Responses in Chronic Hypertension
Yunxia Li 1,2 , Qian Wang 1 , Qiang Shen 1 , Shiliang Huang 1 , Lora Talley Watts 1 , and Timothy Q Duong 1
Research Imaging Institute, The University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States,
of Neurology, Tongji Hospital, Tongji University,
Chronic hypertension increases susceptibility to
neurological disorders. The goal of this study was to
evaluate cerebral blood flow (CBF) and cerebrovascular
reactivity (CR) in response to hypercapnia in an
established rat model of hypertension (SHR) at different
stages of the disease progression. Comparisons were made
with age-matched normotensive Wistar Kyoto (WKY) rats.
CBF and CR were altered in early stage of chronic
hypertension and worsen with disease progression,
ultimately resulting in hypoperfusion and compromised
cerebrovascular reserve. MRI has the potential to be
used to identify brain regions susceptible to
hemodynamic compromise, improve understanding of disease
pathogenesis, guider treatments in hypertension.
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