Abstract #0166
Postischemic Hyperperfusion on Arterial Spin Labeled Perfusion MRI is Linked to Hemorrhagic Transformation in Stroke
Songlin Yu 1 , David S Liebeskind 1 , Sumit Dua 2 , Holly Wilhalme 3 , David Elashoff 3 , Xin J Qiao 2 , Jeffry R Alger 1,2 , Nerses Sanossian 1 , Sidney Starkman 1,4 , Latisha K Ali 1 , Fabien Scalzo 1 , Xin Lou 1,5 , Jeffrey L Saver 1 , Noriko Salamon 2 , and Danny J.J. Wang 1,2
1
Neurology, UCLA, Los Angeles, CA, United
States,
2
Radiology,
UCLA, Los Angeles, CA, United States,
3
Medicine
Statistics Core, UCLA, Los Angeles, CA, United States,
4
Emergency
Medicine, UCLA, Los Angeles, CA, United States,
5
Radiology,
Chinese Peoples Liberation Army (PLA) General Hospital,
Beijing, China
The study investigated the relationship between
postischemic hyperperfusion on arterial spin labeled
(ASL) and hemorrhagic transformation (HT). 361 ASL scans
were collected from 221 acute ischemic stroke patients
(AIS). Hyperperfusion was more frequently detected
post-treatment. Having hyperperfusion at any time point
related significantly to HT (OR=3.5, 95%CI 2.0-6.3,
P<0.001). There was a trend that patients with first
hyperperfusion after 12 hours from stroke onset were
more likely to experience severe HT than those with
first hyperperfusion within 12 hours (Fisher's exact
p-value = 0.06). ASL hyperperfusion may provide an
imaging marker of HT and guide the management of AIS
patients.
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