Velocity and wall shear stress in the Circle of Willis in Sickle Cell Disease using 4D flow MRI
Lena Vaclavu 1 , Henk-Jan Mutsaerts 1 , Wouter Potters 1 , Veronica van der Land 1 , Karin Fijnvandraat 1 , Michael Markl 2 , Charles Majoie 1 , Aart Nederveen 1 , and Pim van Ooij 1
Academic Medical Center AMC, Amsterdam,
& Biomedical Engineering, Northwestern University,
Chicago, IL, United States
Wall shear stress (WSS) is the tangential force exerted
by the flowing blood on the endothelial wall and is
dependent on the dynamic viscosity of blood. ).
Endothelial dysfunction in SCD could be related to low
WSS but this hasnt been studied in the circle of willis
(CoW), whereas low WSS in carotid has been shown to be
atheroprotective.SCD is associated with increased risk
for stroke and vasculopathy and therefore serves as an
interesting patient population to investigate in
relation to WSS. In this pilot study, we explore the
feasibility of 4D flow MRI and WSS estimation in the
CoW, and the Middle Cerebral Artery.
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