Detection of cerebral NAD+ in humans at 7 T
Robin A. de Graaf 1 , Henk M. De Feyter 1 , Peter B. Brown 1 , Terence W. Nixon 1 , Douglas L. Rothman 1 , and Kevin L. Behar 1
MRRC, Yale University, New Haven, CT, United
Nicotinamide adenine dinucleotide (NAD+) has a central
role in cellular metabolism and energy production and is
related to gene expression, calcium mobilization, aging,
cell death and timing of metabolism via the circadian
rhythm. The in vivo detection of NAD+ has traditionally
been limited and has only recently been demonstrated on
rat brain with 1H and 31P NMR spectroscopy. Here the
detection of NAD+ by 1H NMR spectroscopy is extended to
human brain at 7 T. Results are quantitatively compared
to those obtained with in vivo 31P NMR spectroscopy.
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