Abstract #0211
Unravelling the neurochemical mechanism of positive and negative BOLD responses: a combined fMRI-fMRS study
Adam Berrington 1 , Andre Gouws 2 , Stuart Clare 1 , Peter Jezzard 1 , and Uzay Emir 1
1
FMRIB Centre, University of Oxford, Oxford,
United Kingdom,
2
York
Neuroimaging Centre, University of York, York, United
Kingdom
We investigate neurochemical changes associated with the
positive and negative BOLD response. Using a visual
stimulus capable of generating PBR and NBR adjacently in
visual cortex, along with a two-voxel spectroscopy
sequence at 7T, we determine metabolite changes from
resting baseline. The relative increase or decrease of
certain metabolites e.g. glucose and glutamate, between
NBR and PBR, hints at alternate metabolic processes
behind either response. Baseline concentrations of GABA
and glutamate are also found to correlate to negative
BOLD strength suggesting a link between
inhibition-excitation balance and BOLD response.
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