Abstract #0215
Searching for a truly "iso-metabolic" gas challenge for the use in calibrated fMRI and cerebrovascular reactivity mapping
Shin-Lei Peng 1 , Harshan Ravi 1 , Min Sheng 1 , Binu Thomas 1 , and Hanzhang Lu 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States
Hypercapnia challenge has been proposed as a method for
the calibration experiment because CO2 does not alter
brain metabolism. However, the assumption that
hypercapnia challenge is iso-CMRO2 has not been
validated. This study is to investigate a gas challenge
is truly iso-metabolic by adding a hypoxic component
to the hypercapnic challenge (hypercapnic-hypoxia). We
used TRUST MRI to monitor the subjects CMRO2 during
hypercapnic-hypoxia challenge. Our data showed the
neural suppression effect of hypercapnia appears to be
nullified by the metabolic enhancement effect of
hypoxia. We therefore propose hypercapnic-hypoxia is an
iso-metabolic challenge that may be used for calibrated
fMRI studies.
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