Meeting Banner
Abstract #0224

Iron-Oxide Driven Decrease in T2 Relaxation Times Correlates with Tumor Associated Macrophages (TAMs) in Postpartum Pregnancy Associated Breast Cancer Xenografts

J C Montejano 1 , K M Huber 1 , V F Borges 1 , P J Schedin 2 , and N J Serkova 1

1 University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 2 Oregon Health and Science University, Oregon, United States

In this study, superparamagnetic iron nanoparticles (SPION) were used as a contrast agent for the imaging of macrophage driven inflammation in postpartum pregnancy associated breast cancer (PPABC) by T2-MRI. A cohort of immunocompetent BALB/C mice were injected with a murine breast cancer cell line and injected with SPION contrast 24 hours prior to imaging. When compared to virgin counterparts, postpartum mice showed a large decrease in T2 relaxation times. This study has shown that SPIONs are an appropriate contrast agent for the assessment of the TAM-rich tumor microenvironment in PPABC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here