Abstract #0227
Dynamic Contrast Enhanced Magnetic Resonance Imaging Evaluates Early Therapeutic Effect of Anti-EMMPRIN Antibody with Cisplatin or X-radiation in Head and Neck Cancer Mouse Models
Hyunki Kim 1 , Yolanda Hartman 1 , Guihua Zhai 1 , Thomas Chung 1 , Melissa Korb 1 , Tong Zhou 1 , and Eben Rosenthal 1
1
University of Alabama at Birmingham,
Birmingham, AL, United States
Dynamic contrast enhanced magnetic resonance imaging
(DCE-MRI) showed that tumor microvascular perfusion was
significantly suppressed by anti-EMMPRIN antibody alone
or in combination with X-radiation or cisplatin in head
and neck cancer mouse models. The early change of tumor
perfusion parameters following anti-EMMPRIN therapy
with/without cisplatin was significantly correlated with
the tumor volume change, proliferation cell density, and
microvessel density, but not when X-radiation treated
group was included. Therefore DCE-MRI may be used to
predict the therapeutic efficacy of anti-EMMPRIN
antibody with/without cisplatin, but not with
X-radiation.
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