Can MRI of the nigrosomes provide a biomarker for progression of Parkinsons Disease?
Stefan Schwarz 1 , Olivier Mougin 1 , Yue Xing 1 , Ania Blazejewska 1 , Lesley Martin 1 , Nin Bajaj 2 , Dorothee Auer 1 , and Penny Gowland 1
Sir Peter Mansfield Imaging Cetre,
University of Nottingham, Nottingham, Nottinghamshire,
of Neurology, Nottingham University Hospitals NHS Trust,
Nottingham, Nottinghamshire, United Kingdom
Nigrosomes 1-5 can be detected at 7T and are less
visible in PD patients than in controls. The laterality
of loss of the nigrosomes correlates better with disease
laterality than DaTscan results for this group. The
variation in nigrosome visibility and nigrsome T2*w
signal with log(UPDRS) suggests that these measures may
provide a quantitative biomarker of PD progression.
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