Quantitative NMR imaging of the short-T2 components in the SKM tissue: alterations observed in myopathic patients
Ericky Caldas de A. Araujo 1 , Noura Azzabou 1 , Alexandre Vignaud 2 , Genevive Guillot 3 , and Pierre G. Carlier 1,4
NMR Laboratory, Institute of Myology, Paris,
Gif Sur Yvette, le-de-France, France,
University Paris-SUD, Orsay, le-de-France, France,
Laboratory, CEA/I2BM/MIRCen, Paris, le-de-France,
UTE methods offer the possibility of acquiring NMR
signal from protons in the hydration layers of the
collagen. We have applied the UTE method for imaging the
short-T2 signal in SKM tissue, which we hypothesise to
reveal intramuscular connective tissue content.
Dual-echo acquisition and selective long-T2 suppression
methods fail to isolate the short-T2 signals in SKM. We
propose a new method for processing UTE data, resulting
in signal issued exclusively from the short-T2
components in the SKM. The proposed method was applied
to investigate the SKM tissue of eight healthy
volunteers and three patients diagnosed with NMDs.
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