Abstract #0265
A novel multiphase scheme for simultaneous ASL and BOLD acquisition
Paula Croal 1 , Emma Hall 1 , Penny Gowland 1 , and Susan Francis 1
1
Sir Peter Mansfield Imaging Centre,
Department of Physics & Astronomy, The University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom
Simultaneous CBF/BOLD acquisition is important for
calibration of the BOLD signal and to investigate
cerebrovascular reactivity. However, such sequences
commonly rely on single phase ASL, which assumes a
constant transit time and so can be problematic under
high flow environments where transit time changes may
occur (e.g. hypercapnia). We present a multiphase
sequence for simultaneous CBF/BOLD acquisition termed
Lock-Locker Double Acquisition Background Suppressed
(LL-DABS) and compare this to single-phase CBF/BOLD
acquisition. We demonstrate that LL-DABS significantly
increases CBF measured under hypercapnia (P = 0.04),
while BOLD sensitivity is maintained, and show this has
significant implications for CMRO2 measurements.
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