Diffusion Sensitivity of 3D-GRASE in ASL Perfusion
Xiang He 1 , Thang Le 2 , Hoi-Chung Leung 2 , Parsey Ramin 3 , and Mark Schweitzer 1
Department of Radiology, Stony Brook
University, Stony Brook, New York, United States,
of Psychology, Stony Brook University, New York, United
of Psychiatry, Stony Brook University, New York, United
The diffusion sensitivity of ASL perfusion
quantification with 3D-GRASE readout is investigated on
human volunteer subjects. The results demonstrated a
robust under-estimation on gray matter perfusion and
significant over-estimation on white matter perfusion,
especially in sub-cortical white matter. The diffusion
sensitivity of intravascular ASL water signal is
proposed as the root cause of the observed artifacts.
This study suggests that high segmentation factor
acquisition scheme, i.e. 6 or 8 shot (3PR 2PE or 4PAR
2PE), should be applied in GRASE or RARE readout to
reduce the diffusion artifacts.
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