Perfusion/Diffusion mismatch in stroke: what about the hematocrit?
Benjamin Lemasson 1,2 , Alexis Broisat 3,4 , Ligia S. B. Boisserand 1,2 , Mitra Ahmadi 3,4 , Sandrine Bacot 3,4 , Audrey Soubies 3,4 , Olivier Detante 1,5 , Catherine Ghezzi 3,4 , Chantal Rmy 1,2 , and Emmanuel L. Barbier 1,2
Inserm, U836, Grenoble, -, France,
Grenoble Alpes, GIN, Grenoble, -, France,
U1039, Grenoble, -, France,
Grenoble Alpes, Radiopharmaceutiques Biocliniques,
Grenoble, -, France,
de Grenoble, GIN, Grenoble, -, France
MRI and molecular imaging techniques were associated to
map the perfusion (CBF)/diffusion (ADC) mismatch and the
local hematocrit level (Hct) of rats during actute
stroke. The stroke lesion drawn on the CBF maps were
significantly larger than the ones drawn on the ADC maps
which were themselves significantly larger than the ones
drawn on the Hct maps (ROIs sizes: CBF>ADC>Hct). The
mismatch between CBF and Hct suggests that plasmatic and
red blood cell flows are not equivalent during acute
stroke. The ADC/Hct mismatch might be used to determine
a new region of tissue, which could be able to recover.
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