Abstract #0314
Removing the confounding effect of the fat component in ADC quantification of the vertebral bone marrow water component
Michael Dieckmeyer 1 , Stefan Ruschke 1 , Holger Eggers 2 , Hendrik Kooijman 3 , Ernst J. Rummeny 1 , Jan S. Bauer 4 , Thomas Baum 1 , and Dimitrios C. Karampinos 1
1
Diagnostic and Interventional Radiology,
Technische Universitt Mnchen, Munich, Germany,
2
Philips
Research Laboratory, Hamburg, Germany,
3
Philips
Healthcare, Hamburg, Germany,
4
Diagnostic
and Interventional Neuroradiology, Technische
Universitt Mnchen, Munich, Germany
The quantification of the apparent diffusion coefficient
(ADC) of water in vertebral bone marrow has shown merit
towards differentiating between benign and malignant
vertebral compression fractures and towards indirectly
investigating bone matrix changes in patients with
osteoporosis. Vertebral bone marrow contains both water
and fat components. Therefore, the extraction of water
ADC can be biased by incomplete fat suppression of the
secondary fat peaks close to the water peak, when using
a spectrally selective fat suppression technique. The
present work proposes a methodology to correct for the
confounding effect of incomplete fat suppression in bone
marrow water ADC quantification.
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