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Abstract #0325

Effect of Epinephrine on Metabolism of HP [1- 13 C]pyruvate in Low-flow Myocardial Ischemia

Chalermchai Khemtong 1 , Wei Chen 1 , Weina Jiang 1 , Craig R Malloy 1,2 , and A. Dean Sherry 1,3

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Veterans Affairs North Texas Health Care System, Dallas, TX, United States, 3 Chemistry, University of Texas at Dallas, Richardson, TX, United States

Adrenergic agents are widely used to assess cardiac conditions. Hyperpolarized (HP) 13 C-MRS offers direct assessment of metabolic consequences of adrenergic stimulation rather than assessing metabolism based on mechanical function. We tested whether metabolism of HP-[1- 13 C]pyruvate is sensitive to adrenergic stimulation or ischemia in perfused hearts. During normal perfusion conditions, epinephrine increased glycolysis and glycogenolysis to lactate, and production of HP-bicarbonate from [1- 13 C]pyruvate. During ischemia, epinephrine had little effect on the HP-signals after HP-[1- 13 C]pyruvate, because coronary flow could not increase. HP-pyruvate is preferentially converted to alanine rather than lactate during ischemia after epinephrine, indicating compartmentation of HP-pyruvate metabolism in ischemic heart.

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