Abstract #0346
Assessing Diffusion Time Effects on Microstructural Comparment Estimates in Human White Matter using 7T dwSTEAM
Silvia De Santis 1,2 , Derek K Jones 1 , and Alard Roebroeck 2
1
CUBRIC Cardiff University, Cardiff, United
Kingdom,
2
Maastricht
University, Maastricht, Netherlands
The purpose of this work is to analyse the impact of
diffusion time in estimating axonal density and axonal
diameters using STEAM diffusion at 7T. Using a 2-ways
ANOVA, we demonstrate that the estimates of axonal
density obtained at different diffusion times are
significantly different. In addition, by accounting for
the diffusion time dependency of the extra-axonal
signal, we show that estimates of axonal diameter in
agreement with histology can be obtained.
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