A generative model of white matter axonal orientations near the cortex
Michiel Cottaar 1 , Saad Jbabdi 1 , Matthew F Glasser 2 , Krikor Dikranian 2 , David C van Essen 2 , Timothy E Behrens 1 , and Stamatios N Sotiropoulos 1
FMRIB Centre, University of Oxford, Oxford,
University School of Medicine, Saint Louis, Missouri,
Close to the cortical surface axons often bend towards
the surface on a spatial scale unresolved in diffusion
MRI, which causes these bends to be missed by classical
tractography algorithms. Here we present a simple model,
which with a single free parameter can reproduce the
fibre orientation measured in a high-resolution
myelin-stained macaque gyral slice within 4 degrees.
This low-parameter model can be fitted to the dispersion
orbital distribution function measured in diffusion MRI
to reproduce the sub-voxel fibre bending to the cortical
surface and hence the cortical connectivity.
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