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Abstract #0357

LAMINAR DIFFERENCES IN NEURAL ACTIVITY DURING POSITIVE AND NEGATIVE BOLD CONDITIONS

Daniel Zaldivar 1 , Nikos Logothetis 1 , and Jozien Goense 1,2

1 Logothetis, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wrttemberg, Germany, 2 Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom

There is still debate whether negative BOLD responses have a neural or vascular origin. Laminar differences in neurovascular coupling have also been observed during the negative-BOLD response. We investigated whether these differences have a neural origin by performing laminar recordings in V1. We positioned two laminar electrodes in V1; one of these was located in the negative-BOLD area whereas the other in the positive-BOLD area. We observed that the middle cortical layers did not decrease their neural activity while all other layers did, suggesting that the negative BOLD response is driven by the neural activity reductions in the supragranular and infragranular layers.

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