Classification of in vivo drug function through a coupling model and PET/fMRI
Christin Y. Sander 1 , Jacob M. Hooker 1 , Ciprian Catana 1 , Bruce R. Rosen 1,2 , and Joseph B. Mandeville 1
A. A. Martinos Center for Biomedical
Imaging, Massachusetts General Hospital, Harvard Medical
School, Boston, MA, United States,
Sciences and Technology, Harvard-MIT, Cambridge, MA,
The pharmacological response of a drug is currently
defined through in vitro studies and characterized by
parameters such as in vitro efficacy and affinity. We
propose an in vivo classification of drug function by
PET/fMRI and demonstrate a coupling model that can
predict the functional response measured by fMRI.
Experimental results at the D2/D3 dopamine system show
that we can classify agonists and antagonists according
to their fMRI response, suggesting that we can
characterize drug function and efficacy to inform about
the in vivo potency of a drug.
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