Abstract #0366
Comparison of MRI Contrast Enhancement with Molecular Distribution Following FUS-Mediated BBB Opening
Michael Valdez 1 , Shelby Yuan 1 , Zhonglin Liu 1 , Paul Helquist 2 , Terry Matsunaga 1 , Russell Witte 1 , Lars Furenlid 1 , Marek Romanowski 1 , and Ted Trouard 1
1
University of Arizona, Tucson, Arizona,
United States,
2
University
of Notre Dame, Indiana, United States
Treatment of neurological disorders is often hampered by
the inability of therapeutics to cross the blood-brain
barrier (BBB). Techniques that use focused ultrasound
(FUS) and microbubbles have been developed that
temporarily open the BBB. While the opening of the BBB
is readily seen on contrast-enhanced MRI, this only
shows the distribution of contrast agent and not
necessarily the opening to therapeutics. In this work,
we have employed MRI, SPECT, CT, autoradiography, and
fluorescence microscopy in mice to compare the
distribution of contrast agents and model therapeutics
within the brain following FUS-mediated BBB opening.
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