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Abstract #0369

T1 based surrogate MRI marker for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in solid tumors

Michael Peller 1 , Linus Willerding 1,2 , Simone Limmer 2 , Martin Hossann 2,3 , Olaf Dietrich 1 , Michael Ingrisch 1 , Lars Lindner 2,3 , and Maximilian F. Reiser 1

1 Department of Clinical Radiology, University Hospital of Munich, Munich, Germany, 2 Department of Internal Medicine III, University Hospital of Munich, Munich, Germany, 3 CCG Tumor Therapy through Hyperthermia, Helmholtz Zentrum Mnchen, German Research Center for Environmental Health, Munich, Germany

Effectiveness of anti-cancer drugs can be improved by tumor-targeting. Using thermosensitive liposomes such targeting is realized by tumor specific hyperthermia and visualization by loading the TSL with MRI-contrast agents. Purpose of this in vivo study is to test T1-based assessment of hyperthermia induced doxorubicin release in tumors using a mixture of thermosensitive liposomes loaded with a clinically approved contrast agent or doxorubicin, respectively. Assessment of doxorubicin accumulated in heterogeneous tumors tissue seems feasible. This was the first time that a mixture of thermosensitive liposomes loaded either with contrast agent or doxorubicin has been investigated.

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