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Abstract #0384

Assessment of the Hepatocyte Fraction for estimation of liver function

TOMOYUKI OKUAKI 1 , Kosuke Morita 2 , Tomohiro Namimoto 3 , Morikatsu Yoshida 3 , Shinya Shiraishi 3 , Yasuyuki Yamashita 3 , and Marc Van Cauteren 1

1 Philips Healthcare, Minato-ku, Tokyo, Japan, 2 Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan, 3 Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

The hepatocyte fraction(HeF) map is calculated from R1 maps acquired using a breathhold Look-Locker sequence pre and post Gd-EOB-DTPA. Further, the kHep value is calculated as uptake function. The resulting HeF and kHep were compared to the results of 99mTc-GSA scintigraphy. Seventy five patients were classified into four severity levels based on scintigraphy. The median values of the HeF of Normal, Mild, Moderate and Severe were 76.7%, 72.5%, 50.4% and 44.8% respectively. The HeF and kHep decreased with liver function deterioration. The HeF is useful for a robust evaluation of liver function and kHep provides information about hepatic uptake.

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