Advanced Assessment of Liver Diseases with Magnetic Resonance Elastography in Animal Models
Meng Yin 1 , Ruisi Wang 2 , Usman Yaqoob 2 , Shennen A. Mao 3 , Jaime M. Glorioso 3 , Kevin J. Glaser 1 , Liu Yang 2 , Vijay Shah 2 , Scott L. Nyberg 3 , and Richard L. Ehman 1
Radiology, Mayo Clinic, Rochester,
Minnesota, United States,
and Hepatology, Mayo Clinic, Rochester, Minnesota,
Transplatation Surgery, Mayo
Clinic, Rochester, Minnesota, United States
To investigate the utility of MRE-derived mechanical
properties in characterizing diseased hepatic tissue, we
performed multifrequency 3-D/3-axis MRE on two mouse
models with carbon tetrachloride (CCl4) induced chronic
liver injury and one Fumarylacetoacetate hydrolase (FAH)
deficient pig model with chronic liver disease. Liver
stiffness, phase angle, storage and loss modulus
frequency dispersions were selected for evaluation.
Results demonstrated distinct and potentially
characteristic changes in these mechanical properties
with hepatic inflammation, fibrosis and increased portal
pressure. The findings offer preliminary evidence of the
potential to extend MRE to distinguish and independently
assess necroinflammatory and fibrotic processes.
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