Abstract #0391
Arterial Spin Labeling MRI as a Sensitive Imaging Marker of Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Ying Gao 1 , Bernadette O. Erokwu 2 , David A. DeSantis 3 , Colleen M. Croniger 3 , Rebecca M. Schur 1 , Lan Lu 2,4 , Katherine M. Dell 5 , and Chris A. Flask 1,2
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
2
Radiology,
Case Western Reserve University, Cleveland, Ohio, United
States,
3
Nutrition,
Case Western Reserve University, Cleveland, Ohio, United
States,
4
Urology,
Case Western Reserve University, Cleveland, Ohio, United
States,
5
Pediatrics,
Case Western Reserve University, Cleveland, Ohio, United
States
ARPKD is a potentially lethal multi-organ disease
characterized by both polycystic kidneys and congenital
hepatic fibrosis (CHF). Unfortunately, there are
currently no non-invasive methods to monitor CHF in
ARPKD patients limiting the study of potential
therapeutic interventions. Herein, we perform an initial
investigation of liver perfusion measured by Arterial
Spin Labeling (ASL) MRI. Longitudinal liver perfusion
data were acquired from PCK rats at 2 months and 3
months of age using an ASL-FISP technique. Initial
results suggest that liver perfusion as measured by ASL
MRI may provide a sensitive and non-invasive imaging
biomarker to safely monitor ARPKD liver disease
progression.
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