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Abstract #0394

Comparing in vivo and ex vivo imaging in an Alzheimers mouse model using tensor-based morphometry

Holly Elizabeth Holmes 1 , Nicholas Powell 1,2 , Jack Wells 1 , Niall Colgan 1 , Ozama Ismail 1 , James O'Callaghan 1 , Da Ma 1,2 , Michael J O'Neill 3 , Emily Catherine Collins 4 , Manuel Jorge Cardoso 2 , Marc Modat 2 , Elizabeth Fisher 5 , Sebastian Ourselin 2 , and Mark F Lythgoe 6

1 Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom, 2 Centre for Medical Image Computing, University College London, London, Greater London, United Kingdom, 3 Eli Lilly & Co. Ltd, Windlesham, Surrey, United Kingdom, 4 Eli Lilly & Company, Indianapolis, United States, 5 Department of Neurodegenerative Diseases, University College London, London, Greater London, United Kingdom, 6 University College London, London, Greater London, United Kingdom

The tradeoffs when imaging mouse models of neurodegenerative disease using in vivo and ex vivo MRI have been explored using the rTg4510 mouse model of Alzheimer's disease

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