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Abstract #0395

Probing in vivo T2 relaxation time alterations in the corpus callosum of a mouse model of Alzheimers disease

Firat Kara 1,2 , Steffen Roner 3 , Annemie Van der Linden 1 , Huub J.M. de Groot 2 , and A. Alia 2,4

1 Bioimaging Lab, University of Antwerp, Antwerp, Belgium, 2 Leiden Institute of Chemistry, Gorlaeus Laboratoria, Leiden University, Leiden, Netherlands, 3 Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany, 4 Institute of Medical Physics and Biophysics, Leipzig University, Leipzig, Germany

The transverse relaxation time (T2) measurements are sensitive to explore subtle microstructural changes in the corpus callosum. There is an emergent need for new in vivo non-invasive studies to monitor corpus callosum (CC) changes longitudinally in order to clarify how and when the integrity of CC alters in Alzheimers disease (AD). In this study we probed in vivo T2 changes longitudinally in the CC of a mouse model of AD with age and investigated potential biological mechanisms, such as demyelination, Aβ deposition and gliosis, contributing alterations in the biophysical environment of the CC.

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