In Vivo pH Imaging of Mouse Kidneys Using a Frequency-Dependent paraCEST Agent
Yunkou Wu 1 , Shanrong Zhang 1 , Todd C Soesbe 1 , and A. Dean Sherry 1,2
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, TX, United States,
of Chemistry, The University of Texas at Dallas,
Richardson, TX, United States
This study is to explore the feasibility of using a
frequency-dependent paraCEST agent for in vivo pH
imaging of mouse kidneys. CEST signals were acquired
with a steady state gradient echo pulse sequence. The B0
magnetic field inhomogeneities were corrected using
WASSR method. Kidney pH maps were derived by following
the resonance frequencies of the paraCEST agent signals.
The pH maps show the expected pH gradient across the
renal cortex, medulla and pelvis in healthy mice. This
studies provide a direct measure of Kidney pH maps
without the prior knowledge of the paraCEST contrast
agent concentration in vivo.
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