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Abstract #0422

In Vivo Quantification of ATP Synthesis Rates in Rat Skeletal Muscle by 31 P Spectroscopic Magnetic Resonance Fingerprinting

Charlie Yi Wang 1 , Yuchi Liu 1 , Mark Alan Griswold 1,2 , and Xin Yu 1,2

1 Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Radiology, Case Western Reserve University, Cleveland, Ohio, United States

ATP synthesis through ATP synthase rate measurement by conventional 31 P saturation transfer (ST) methods requires long experiment times. A novel 31 P magnetization transfer spectroscopic magnetic resonance fingerprinting (MT-MRF) pulse sequence was designed to encode magnetization transfer of ATP metabolites. The flexibility in sequence design was utilized to improve encoding of magnetization transfer through ATP synthase. Measurement using 31 P MT-MRF method was shown in vivo rat hind-limb to agree with conventional ST method for ATP synthesis rate measurement. 31 P MT-MRF exhibited improved measurement precision over ST for rate measurement of ATP synthesis through ATP synthase, suggesting decreased required imaging time.

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