Diffusion-Weighted MR Spectroscopy feasibility in clinical studies at 3 T : the effect of reducing the acquisition time investigated by bootstrapping
Francesca Branzoli 1,2 , Daniel Garcia-Lorenzo 1,2 , Romain Valabrgue 1,2 , and Stephane Lehricy 1,2
Institut du Cerveau et de la Moelle pinire
ICM, Centre de Neuroimagerie de Recherche CENIR,
Universit, Universit Pierre et Marie Curie and Inserm
UMR-S1127; CNRS, UMR 7225, Paris, France
Diffusion-weighted MR Spectroscopy (DW-MRS) allows to
measure the diffusion properties of intra-cellular
metabolites in-vivo, and in recent years it has been
proved a powerful tool to investigate brain tissue
microstructure and function in both healthy and disease.
However, due to the low concentration of brain
metabolites, the applicability of DW-MRS in clinical
protocols may be prevented by the long acquisition times
often required by this technique. In this study, we
simulated the variability of the apparent diffusion
coefficients (ADCs) of total n-acetylaspartate (tNAA),
total creatine (tCr) and choline compounds (tCho)
associated with different acquisition schemes of
different durations, and propose a short and efficient
acquisition protocol to be used in clinical application.
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