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Abstract #0431

Diffusion spectrum imaging connectomics: a biomarker for staging in psychotic disorders

Alessandra Griffa 1,2 , Philipp S Baumann 3,4 , Carina Ferrari 3,4 , Tanja Eric 3,4 , Philippe Conus 3,4 , Kim Q Do 3,4 , Jean-Philippe Thiran 1,2 , and Patric Hagmann 1,2

1 Signal Processing Laboratory 5 (LTS5), cole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 2 Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland, 3 Service of General Psychiatry and Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland, 4 Naional Center of Competence in Research (NCCR) SYNAPSY - The Synaptic Bases of Mental Diseases, Switzerland

Schizophrenia is a severe psychiatric disorder hypothesized to result from brain connectivity impairment. According to the concept of clinical staging in psychotic disorders, brain connectivity might by more abnormal in more severe stages of the pathology, and altered connectivity measures might show progressive changes from prodromal to chronic phase. In this diffusion spectrum imaging (DSI) study we identify possible network-based biomarkers of pathology progression from early psychosis to chronic schizophrenia stage, compared to healthy subjects.

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